Implementing Best Practices Across the Continuum of Care to Prevent Overdose: A Roadmap for Governors contains recommendations that represent evidence-based and promising actions states and territories can consider as they work to strengthen the Continuum of Care for people at risk for overdose, including those with Substance Use Disorder (SUD). This Roadmap is a product of guidance and information from more than 30 subject matter experts, including more than 20 states and territories, the O’Neill Institute at Georgetown University Law Center, as well as extensive literature on this topic. These recommendations are oriented from a public health perspective and exclusively focused on overdose prevention. They reflect the current landscape of overdose and risk, which has shifted significantly since the 2016 NGA publication, Finding Solutions to the Prescription Opioid and Heroin Crisis: A Roadmap for States, and is now primarily driven by illicitly manufactured fentanyl rather than prescription opioids.